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BN41638R-50ul
50ul
￥1486.00
交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA
BN41638R-100ul
100ul
￥2360.00
交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA
BN41638R-200ul
200ul
￥3490.00
交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA
產(chǎn)品描述
| 英文名稱 | Neurocan |
| 中文名稱 | 神經(jīng)粘蛋白抗體 |
| 別 名 | Chondroitin sulfate proteoglycan 3; Cspg3; NCAN; NEUR; Neurocan core protein; NCAN_HUMAN. |
| 研究領(lǐng)域 | 發(fā)育生物學(xué) 神經(jīng)生物學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 140kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Neurocan:1185-1257/1257 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Neurocan is the major soluble chondroitin sulfate proteoglycan in the brain. It is thought to play a functional role in axonal growth and guidance and in the establishment of specific neural pathways during embryonic brain development. Neurocan expression in the brain is developmentally regulated. Early on the major form of neurocan consists of a 245kD core protein with approximately two chondroitin sulfate glycosoaminoglycan chains of 22kD each. Later neurocan comprises a 180kD core protein Both forms of neurocan contain only chondroitin 4-sulfate glycosoaminoglycan chains. By virtue of their high expression at sites of neural damage and trauma, chondroitin sulfate proteoglycans, including neurocan, are thought to inhibit successful nerve regeneration. Alternative names: Chondroitin sulfate proteoglycan 3; Cspg3; NCAN; NEUR; Neurocan core protein. Function: May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. Subcellular Location: Secreted. Tissue Specificity: Brain. Similarity: Belongs to the aggrecan/versican proteoglycan family. Contains 1 C-type lectin domain. Contains 2 EGF-like domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 2 Link domains. Contains 1 Sushi (CCP/SCR) domain. SWISS: P55066 Gene ID: 1463 Database links: Entrez Gene: 1463 Human Omim: 600826 Human SwissProt: O14594 Human Unigene: 169047 Human Unigene: 10177 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology） 神經(jīng)粘蛋白(Neurocan)是由神經(jīng)元分泌的特異性蛋白質(zhì),廣泛分布于神經(jīng)系統(tǒng),可與神經(jīng)元細(xì)胞膜上特異性受體神經(jīng)粘附分子和神經(jīng)元膠質(zhì)細(xì)胞黏附分子結(jié)合,調(diào)節(jié)細(xì)胞連接,影響軸突生長(zhǎng).而在中樞神經(jīng)系統(tǒng)損傷后,Neurocan的表達(dá)增加,并抑制軸突生長(zhǎng).Neurocan在中樞神經(jīng)系統(tǒng)的形成和損傷后的修復(fù)都扮演著重要的角色. |
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